Medical conditions
that cause hypogonadism

So what causes hypogonadism due to certain medical conditions?

Hypogonadism is also known as Low Testosterone and can be caused by certain medical conditions. It occurs when a man’s testosterone levels fall below the normal range. There could be a signaling problem between your brain and testes that is causing the production of testosterone to drop too low. So if the brain feels that there is too much testosterone in the body, it can signal the testes to cut production. This is known as secondary hypogonadism. Hypogonadism can also occur when there is a defect in your testes and they can’t make levels of testosterone in the normal range. This is known as primary hypogonadism.

Possible Causes of Primary Hypogonadism:

  • Undescended or absent testes
  • Injury resulting in loss of testes
  • Inflammation of the testes
  • Surgical removal of testes
  • Genetic abnormalities, such as Klinefelter Syndrome, in which males have an extra "X" chromosome
  • Chemotherapy that causes loss of normal testicular function
  • Damage to testes from alcohol or heavy metals

Possible Causes of Secondary Hypogonadism:

  • Genetic abnormalities that result in abnormal function of the hormones from the brain and pituitary that control the testes
  • Tumor, trauma, or radiation that involve the pituitary gland's control of the testes

Only your doctor can confirm a diagnosis by taking a medical history, including an evaluation of conditions that may be causing low testosterone levels, performing important medical exams, and measuring testosterone levels with blood tests.

Key points

  • Hypogonadism may occur due to a signaling problem between the brain and testes.
  • Hypogonadism, also known as Low Testosterone, can be caused by certain medical conditions that create a problem with the testes and/or the parts of the brain that regulate the testes.
USE: AndroGel® (testosterone gel) 1% and 1.62%

AndroGel® (testosterone gel) 1% and 1.62% are controlled substances, available by prescription, used to treat adult males who have low or no testosterone due to certain medical conditions. It is not known if AndroGel is safe or effective to treat men who have low testosterone due to aging. It is not known if AndroGel is safe or effective in children younger than 18 years old. Testosterone products that are applied to the skin may have different doses, strengths, or application instructions that may lead to different levels of testosterone in your body.

Important Safety Information

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088or call 1-800-FDA-1088.

If you cannot afford your medication, contact for assistance.

Click here for Use and Important Safety Information.

Please see the full Prescribing Information for AndroGel on this website for more information.

References: 1. AndroGel 1.62% [package insert]. North Chicago, IL: AbbVie Inc. 2. AndroGel 1% [package insert]. North Chicago, IL: AbbVie Inc.