What is AndroGel 1.62%?

AndroGel 1.62%, a controlled substance (CIII), is a topical daily testosterone replacement therapy (TRT) that can help bring your testosterone levels back to normal with daily morning use. This clear, odorless, and concentrated quick-drying gel is used to treat adult males who have low or no testosterone due to certain medical conditions. It should not be used in adult men who have low testosterone as a result of aging alone. AndroGel 1.62% contains testosterone, which is absorbed through the skin after application. The testosterone in AndroGel 1.62% is the same as the testosterone your body makes naturally.

Benefits and risks of AndroGel 1.62%

In a clinical study of 274 men who had low testosterone, some used AndroGel 1.62% and some used placebo.

The AndroGel 1.62% pump inside a bathroom cabinet

Of the men who used AndroGel 1.62% once daily for 16 weeks, 82% had their testosterone levels returned to normal compared to 37% of those who used placebo.

The most common side effects of AndroGel 1.62% are increased prostate specific antigen (a test used to screen for prostate cancer), mood swings, high blood pressure, increased red blood cell count, and skin irritation where the gel is applied.

Safety Considerations

AndroGel 1.62% can cause serious side effects, including worsening symptoms of an enlarged prostate; possible increased risk of prostate cancer; blood clots in the legs or lungs; possible increased risk of heart attack or stroke; lower sperm count; swelling of ankles, feet, or body; enlarged or painful breasts; and problems breathing during sleep. Before you use AndroGel, tell your doctor if you have breast cancer; prostate cancer; urinary problems due to enlarged prostate; heart, kidney, or liver problems; problems breathing while you sleep (sleep apnea); or have any other medical conditions.

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