What is hypogonadism due to certain medical conditions?

Hypogonadism occurs when a man’s testosterone levels fall below the normal range of 300 ng/dL to 1000 ng/dL. It can occur when there is a defect in your testes and they can’t produce levels of testosterone in the normal range. This is known as primary hypogonadism. There could also be a signaling problem between your brain and testes that is causing the production of testosterone to drop too low. This is called secondary hypogonadism.

AndroGel 1.62% is only approved for men with low testosterone that could be caused by certain medical conditions. You can learn more about these medical conditions by reading the lists below and having a conversation with your doctor.

Possible Causes of Primary Hypogonadism:

  • Undescended or absent testes
  • Injury resulting in loss of testes
  • Inflammation of the testes
  • Surgical removal of testes
  • Genetic abnormalities, such as Klinefelter’s syndrome, in which males have an extra "X" chromosome
  • Chemotherapy that causes loss of normal testicular function
  • Damage to the testes from alcohol or heavy metals

Possible Causes of Secondary Hypogonadism:

  • Genetic abnormalities that result in abnormal function of the hormones from the brain and pituitary that control the testes
  • Tumor, trauma, or radiation that involves the pituitary gland's control of the testes

Diagnostic testing

Once your doctor has performed an exam and reviewed your medical history to determine if there is an underlying condition that may be causing low testosterone levels, he or she can evaluate if your testosterone should be measured using standard blood tests.

A physician inspects a patient's blood sample during a testosterone diagnosis

Testosterone levels can vary from day to day, and by time of day, so typically two morning blood tests are needed to make a hypogonadism diagnosis.

There are two types of blood tests that can be done to measure your testosterone. The most common test measures the total testosterone in your body. Your doctor may also order a free testosterone test as well as additional tests to help confirm a diagnosis. Since testosterone levels are at their peak in the morning, it’s recommended that blood tests are performed in the morning.

Testosterone levels can vary from day to day, and by time of day, so typically two morning blood tests are needed to make a hypogonadism diagnosis. The first blood test will give your doctor a baseline. The second test confirms your levels and helps confirm a diagnosis of hypogonadism.

It is important to know that AndroGel 1.62% is not meant for use in women, children under the age of 18, or men with low testosterone due to aging alone.

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