In some clinical studies, a small percentage of men reported acne, prostate disorders, skin irritation, breast enlargement, and trouble urinating.

The most frequent adverse events reported by ≥5% of patients associated with the consistent use of AndroGel included abnormal lab test, acne, prostate disorder, and application site reaction.

Elderly patients treated with androgens may be at an increased risk for the development of an enlarged prostate and prostate cancer.